Tobias J. Tuthill

Induction of neutralising antibodies against conserved rhinovirus capsid protein VP4 depends on presenting VP4 in a virus-like conformation

This study shows that presenting VP4 peptides in a virus-like conformation induces neutralising antibodies in mice, highlighting the importance of antigenic conformation for vaccine design.

The assembly of stress granule-like foci during foot-and-mouth disease virus infection is uncoupled from activation of cellular intrinsic antiviral signalling

This study shows that stress granule formation during FMDV infection is independent of innate immune activation, and that preventing their disassembly reduces viral replication.

ITAF45 is a Pervasive Trans Acting Factor for Picornavirus Type II IRES Elements

The paper identifies ITAF45 as a host factor essential for picornavirus Type II IRES-mediated translation, showing its role in multiple viruses and suggesting it as an antiviral target.

The pseudoknot region and poly-(C) tract comprise an essential RNA packaging signal for assembly of foot-and-mouth disease virus

This study identifies the pseudoknot region and poly-(C) tract as essential RNA packaging signals for foot-and-mouth disease virus (FMDV) assembly, showing that their length and interactions influence packaging efficiency.

The dual role of a highly structured RNA (the S fragment) in the replication of foot-and-mouth disease virus.

This study investigates the role of the conserved S fragment in FMDV replication using SHAPE and genomic analyses, revealing its structural importance and interaction with 3Dpol.

The RNA pseudoknots in foot-and-mouth disease virus are dispensable for genome replication but essential for the production of infectious virus.

This study shows that RNA pseudoknots in FMDV are not required for genome replication but are essential for producing infectious virus.