Mehdi Amiri

This study identifies a synergistic therapeutic effect of combining MNK1/2 inhibition with G1/S CDK blockade in triple-negative breast cancer.

This study shows that translational control in spinal cord neurons, particularly in inhibitory and PV+ interneurons, significantly influences gene expression and pain hypersensitivity during the chronic phase of neuropathic pain.

This paper shows eIF2B activates mutant KRAS by forming a complex with SOS at the plasma membrane and regulating glycosphingolipid biosynthesis.

The paper identifies ITAF45 as a host factor essential for picornavirus Type II IRES-mediated translation, showing its role in multiple viruses and suggesting it as an antiviral target.

The paper investigates the role of FMRP in neuronal RNA granules containing stalled ribosomes and finds that its loss affects granule stability but not ribosome stalling sites.

This study identifies M19-6 as a small molecule that disrupts the eIF4F complex, reducing melanoma growth and metastasis while sparing melanocytes.