Cell BiologybioRxivPreprint
Aberrant Wnt activation in recurrent genetically variant human pluripotent stem cells impairs cardiomyocyte differentiation and phenotype
Theodore Wing, Christopher J. Price, Dylan Stavish…·Ivana Barbaric
This study shows that genetic variants in human pluripotent stem cells, specifically gains of chromosome 1q, impair cardiomyocyte differentiation and phenotype through aberrant Wnt activation.
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