AMPK-dependent FLCN phosphorylation activates a survival response to hypoxia
Josué M. J. Ramírez-Reyes, Ariadna Pollato-Blanco, Stéphanie Duhamel, Steven Hébert, Claudia L. Kleinman, Bhushan Nagar, Morag Park, Josie Ursini‐Siegel, Arnim Pause
The paper identifies an AMPK-FLCN-TFE3 pathway that promotes hypoxia survival through lysosomal and mitochondrial biogenesis, with implications for cancer therapy.
bioRxiv · May 22, 2026 · PreprintBiochemistry