Josie Ursini‐Siegel

The paper introduces INSIGHT, a platform for phosphoproteomic analysis of rare cell subpopulations, and applies it to study signaling changes in disseminated glioblastoma cells in vivo.

This study identifies a lactate-fueled metabolon involving LDHB and HTC that promotes breast cancer metastasis by reprogramming NAD metabolism.

The paper identifies an AMPK-FLCN-TFE3 pathway that promotes hypoxia survival through lysosomal and mitochondrial biogenesis, with implications for cancer therapy.

This study shows that mitochondrial ETF insufficiency promotes cancer growth by reprogramming bioenergetics and signaling pathways in neoplastic cells.

This study shows that both mTOR activation and inhibition increase H3K27me3 through distinct mechanisms, and this epigenetic change correlates with the anti-proliferative effects of mTOR inhibitors.

This study identifies POGZ as a regulator of HP1-dependent DNA repair, showing its role in homology-directed repair and its clinical relevance to White Sutton syndrome.