Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility
Eden M. Anderson, Steven Loke, Benjamin Wrucke, Annabel Engelhardt, Skyler Demis, Kevin O’Reilly, Evan M. Hess, Kevin D. Wickman, Matthew C. Hearing
This study shows that GIRK channel signaling in male mice is critical for prelimbic cortical function and stress-induced cognitive flexibility, but not in females.
Neuropsychopharmacology · Jun 22, 2021Peer-reviewedNeuroscience