Kevin D. Wickman

This paper develops AAV-m5, a nanobody-functionalized AAV vector that targets neurons via mGluR5, achieving efficient and specific transduction in the CNS without relying on promoters.

This paper develops an AAV-only method to target VTA dopamine neurons in mice for optogenetic studies, achieving high efficiency and fidelity.

The paper shows mild depolarization in neurons triggers immediate early genes and temporarily reduces responses to subsequent stimuli.

This study shows that GIRK channel signaling in male mice is critical for prelimbic cortical function and stress-induced cognitive flexibility, but not in females.

This study shows that PKCε regulates Chrna6 and Chrnb3 expression differently in male and female mice, affecting nicotine and alcohol behavior.

The paper investigates how enhancing pyramidal neuron excitability in the prelimbic cortex affects behavior, finding that such manipulations replicate cocaine-induced behavioral changes.