Tumor-specific CD4 T cells cooperate with myeloid cells to remodel the pancreatic tumor microenvironment and enable effective immunotherapy
Eduardo Cruz-Hinojoza, Zoe C. Schmiechen, Sindri M Bonner, Adam L. Burrack, Madeline A. Ellefson, Rachana Pandey, Amrit Gaire, Sandhya Appiah, Steven S. Shen, Thamotharampillai Dileepan, Ingunn M. Stromnes
The paper shows that tumor-specific CD4 T cells, when activated with MHC-II tetramers and anti-CD40, remodel the pancreatic tumor microenvironment to enhance immunotherapy.
bioRxiv · Aug 1, 2026 · PreprintImmunology