Author

Adam L. Burrack

University of MinnesotaORCID 0000-0002-4001-7849Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ingunn M. StromnesiD· 3 shared Alexander K. TsaiiD· 2 shared Eduardo Cruz-HinojozaiD· 2 shared Madeline A. EllefsoniD· 2 shared Zoe C. SchmiecheniD· 2 shared Adam J. DupuyiD· 1 shared Alex T. LarssoniD· 1 shared Amrit GaireiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersImmunology

Ingunn M. StromnesORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologyJournal for ImmunoTherapy of CancerPeer-reviewedOct 1, 2026

Abrogating TGFβ signaling in TCR-engineered T cells and enhancing antigen processing by tumor cells promotes sustained therapeutic activity in pancreatic ductal adenocarcinoma

Alexander K. Tsai, Meagan R. Rollins, Madeline A. Ellefson…·Ingunn M. Stromnes

This study shows that blocking TGFβ signaling in TCR-engineered T cells and enhancing antigen processing in tumor cells improves their therapeutic effectiveness against pancreatic ductal adenocarcinoma.

1 citation

mouseproteomics

𝕏 PostBluesky

ImmunologybioRxivPreprintAug 1, 2026

Tumor-specific CD4 T cells cooperate with myeloid cells to remodel the pancreatic tumor microenvironment and enable effective immunotherapy

Eduardo Cruz-Hinojoza, Zoe C. Schmiechen, Sindri M Bonner…·Ingunn M. Stromnes

The paper shows that tumor-specific CD4 T cells, when activated with MHC-II tetramers and anti-CD40, remodel the pancreatic tumor microenvironment to enhance immunotherapy.

DOI 10.64898/2026.07.28.741325

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologyJournal for ImmunoTherapy of CancerPeer-reviewedJul 1, 2026

Sleeping Beauty mutagenesis identifies BACH2 and other regulators of CD8+T cell exhaustion, persistence in vivo, and CAR-T function under tumor-associated chronic antigen stimulation

Chang-Jung Lee, Alex T. Larsson, Tyler A. Jubenville…·David A. Largaespada

The paper uses Sleeping Beauty mutagenesis to identify BACH2 and other genes that enhance CD8+ T cell persistence and function under chronic antigen stimulation, improving engineered T cell therapies.

1 citation

mousescRNA-seq

𝕏 PostBluesky