Author

Zoe C. Schmiechen

University of MinnesotaORCID 0000-0002-3403-6824Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Adam L. BurrackiD· 2 shared Eduardo Cruz-HinojozaiD· 2 shared Ingunn M. StromnesiD· 2 shared Madeline A. EllefsoniD· 2 shared Alexander K. TsaiiD· 1 shared Amrit GaireiD· 1 shared Ayaka Hulbert· 1 shared David MasopustiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersImmunology

Adam L. BurrackORCID

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2 papers

Recent·Most cited

ImmunologyJournal for ImmunoTherapy of CancerPeer-reviewedOct 1, 2026

Abrogating TGFβ signaling in TCR-engineered T cells and enhancing antigen processing by tumor cells promotes sustained therapeutic activity in pancreatic ductal adenocarcinoma

Alexander K. Tsai, Meagan R. Rollins, Madeline A. Ellefson…·Ingunn M. Stromnes

This study shows that blocking TGFβ signaling in TCR-engineered T cells and enhancing antigen processing in tumor cells improves their therapeutic effectiveness against pancreatic ductal adenocarcinoma.

1 citation

mouseproteomics

ImmunologybioRxivPreprintAug 1, 2026

Tumor-specific CD4 T cells cooperate with myeloid cells to remodel the pancreatic tumor microenvironment and enable effective immunotherapy

Eduardo Cruz-Hinojoza, Zoe C. Schmiechen, Sindri M Bonner…·Ingunn M. Stromnes

The paper shows that tumor-specific CD4 T cells, when activated with MHC-II tetramers and anti-CD40, remodel the pancreatic tumor microenvironment to enhance immunotherapy.

DOI 10.64898/2026.07.28.741325

humanbulk RNA-seq