Targeted cancer ablation via programmable sensing of amplified oncogenic RNA
Meng Zhang, Yixin Hu, Sean A. Yamada-Hunter, Elena Sotillo, Haoyu Dai, Connor C. Call, Aidan Michael Tousley, Stewart J. Kim, Wanting Liu, Monte M Winslow, Crystal Mackall, Xiaojing J Gao
This paper introduces ORCA, a platform that uses oncogenic RNA sensing to target and ablate cancer cells, demonstrating efficacy in colorectal cancer models.
bioRxiv · Nov 3, 2026 · PreprintSynthetic Biology