Tripolar mitosis drives the association between maternal genotypes of PLK4 and aneuploidy in human preimplantation embryos
Rajiv C. McCoy, Louise J Newnham, Christian Simon Ottolini, Eva R. Hoffmann, Katerina Chatzimeletiou, Omar E. Cornejo, Qiansheng Zhan, Nikica Zaninović, Zev Rosenwaks, Dmitri A. Petrov, Zachary Demko, Styrmir Sigurjonsson, Alan H. Handyside
The paper identifies tripolar mitosis as a mechanism causing aneuploidy in human embryos and links it to maternal PLK4 genetic variants.
Human Molecular Genetics · Apr 20, 2018Peer-reviewedGenetics