Fenretinide targets GATA1 to induce cytotoxicity in GATA1 positive Acute Erythroid and Acute Megakaryoblastic Leukemic cells.
Yasharah Raza, Manal Elmasry, Guoying Yu, Sam B Chiappone, Suhu Liu, Chiara Luberto
This paper identifies Fenretinide as a GATA1-targeting agent that induces cytotoxicity in M6 and M7 AML cells by causing GATA1 loss and overcomes chemotherapeutic resistance.
bioRxiv · Jan 19, 2025 · PreprintCancer Biology