This study identifies the role of 5' and 3' UTRs in SARS-CoV-2 genome packaging by showing their interaction with the PS9 element and enhancing packaging efficiency.

Viruses · Jun 25, 2026Peer-reviewedMicrobiology

Fenretinide targets GATA1 to induce cytotoxicity in GATA1 positive Acute Erythroid and Acute Megakaryoblastic Leukemic cells.

Yasharah Raza, Manal Elmasry, Guoying Yu, Sam B Chiappone, Suhu Liu, Chiara Luberto

This paper identifies Fenretinide as a GATA1-targeting agent that induces cytotoxicity in M6 and M7 AML cells by causing GATA1 loss and overcomes chemotherapeutic resistance.

bioRxiv · Jan 19, 2025 · PreprintCancer Biology

LAPTM4B Alleviates Pulmonary Fibrosis by Enhancing NEDD4L-Mediated TGF-beta Signaling Suppression

Kai Xu, Xiaoyue Pan, Hui Lian, Yaxuan Wang, Ruyan Wan, Zhongzheng Li, Xin Pan, Yajun Li, Juntang Yang, Iván O. Rosas, Lan Wang, Guoying Yu

bioRxiv · Aug 30, 2024 · PreprintCell Biology

Proteomic Characterization of Serum Small Extracellular Vesicles in Human Breast Cancer

Ganfei Xu, Weiyi Huang, Shaoqian Du, Minjing Huang, Jiacheng Lyu, Fei Zhou, Rongxuan Zhu, Yuan Cao, Jingxuan Xv, Ning Li, Guoying Yu, Bing‐Hua Jiang, Olivier Gires, Lei Zhou, Hongwei Zhang, , Hongxia Wang

The paper characterizes serum small extracellular vesicles (sEVs) proteomics in breast cancer patients, identifying distinct protein signatures and potential biomarkers for diagnosis and prognosis.

bioRxiv · Nov 26, 2021 · PreprintBioinformatics