Ablation of the evolutionarily acquired functions of the Atp1b4 gene in mice protects against obesity and increases metabolic capacity
Nikolaï N. Modyanov, Lucia Russo, Sumona L. Ghosh, Tamara R. Castañeda, Himangi G. Marathe, R. E. Bourey, Sonia Michael Najjar, Ivana L. de la Serna
This study shows that ablating the Atp1b4 gene in mice reduces obesity and improves metabolic parameters by disrupting evolutionarily acquired BetaM functions.
bioRxiv · Feb 26, 2025 · PreprintEvolutionary Biology