Lucia Russo

Defective insulin clearance plays a primary role in the pathogenesis of chronic kidney disease in mice with null deletion of Ceacam2 gene

This study shows that loss of CEACAM2 in mice impairs renal insulin clearance, leading to hyperinsulinemia, insulin resistance, and kidney dysfunction.

Ablation of the evolutionarily acquired functions of the Atp1b4 gene in mice protects against obesity and increases metabolic capacity

This study shows that ablating the Atp1b4 gene in mice reduces obesity and improves metabolic parameters by disrupting evolutionarily acquired BetaM functions.