Bnip3lb-driven mitophagy sustains expansion of the embryonic hematopoietic stem cell pool
Eleanor Meader, Morgan T. Walcheck, Mindy Leder, Patrice Delaney, Marcelo Falchetti, Ran Jing, Christopher Li, Netra K. Kambli, Paul J. Wrighton, Wade W. Sugden, Mohamad Ali Toufic Najia, Isaac M. Oderberg, Vivian M. Taylor, Zachary C. LeBlanc, Eleanor D. Quenzer, , Trista E. North
This study shows that Bnip3lb-driven mitophagy maintains embryonic HSPC multipotency and expansion by regulating ROS levels, and enhances ex vivo hematopoietic potential of iPSC-derived HSPCs.
Nature Communications · Feb 24, 2026Peer-reviewedCell Biology