Trista E. North

This study shows that hemodynamic forces activate YAP signaling via Piezo1 in hemogenic endothelium, promoting HSC production by regulating metabolic and gene regulatory programs, while TAZ overactivation disrupts this balance.

This paper identifies small-molecule modulators that enhance the generation of functional cytotoxic T cells from hiPSCs, increasing CTL production up to 2000-fold.

This study shows that Bnip3lb-driven mitophagy maintains embryonic HSPC multipotency and expansion by regulating ROS levels, and enhances ex vivo hematopoietic potential of iPSC-derived HSPCs.

The paper identifies ZCCHC6 and DIS3L2 as key regulators of RNA decay during terminal erythropoiesis, showing their role in post-transcriptional globin switching and {gamma}-globin stabilization.

The paper identifies KDM4 demethylase inhibition as a therapeutic strategy for lymphoma and other cancers by rewiring heterochromatin and inducing DNA damage.

This study identifies Erg as a master transcription factor whose upregulation during aging is critical for adult hematopoietic stem cell function and resistance to leukemogenesis.

This paper designs soluble multivalent Notch agonists to activate Notch signaling in vitro, enabling T cell differentiation and immunotherapy development.

The paper identifies a Lin28b-let-7-PRC1 axis that regulates hematopoietic maturation across development, with Cbx2 playing a key role in controlling developmental timing of hematopoietic transcription factors.