CRISPR/Cas9-mediated gene editing induces neurological recovery in an A53T-SNCA overexpression rat model of Parkinson's disease
Hyung Ho Yoon, Sunghyeok Ye, Sunhwa Lim, Ara Jo, Hawon Lee, Felix Hong, Seung Eun Lee, Soo‐Jin Oh, Narae Kim, Kyoungmi Kim, Bum-Joon Kim, Hyun‐Jin Kim, Changjoon Justin Lee, Min‐Ho Nam, Junseok W. Hur, Sang Ryong Jeon
This study uses CRISPR/Cas9 to delete A53T-SNCA in a rat model of Parkinson's disease, showing reduced -synuclein levels and improved motor symptoms.
The CRISPR Journal · Feb 1, 2022Peer-reviewedGenetics