Omer Habib

Detailed mechanisms for unintended large DNA deletions with CRISPR, base editors, and prime editors

The paper identifies mechanisms by which CRISPR, base editors, and prime editors cause large DNA deletions and proposes strategies to mitigate them.

Comprehensive analysis of prime editing outcomes in human embryonic stem cells

This paper tests prime editing in human pluripotent stem cells, showing it can induce various genetic modifications and correct disease mutations without off-target effects from the reverse transcriptase domain.

DNA-dependent RNA cleavage by the Natronobacterium gregoryi Argonaute

The paper demonstrates that NgAgo from Natronobacterium gregoryi cleaves RNA instead of DNA, functioning as a DNA-guided endoribonuclease.