Kyoungmi Kim

The paper uses AI to generate a small MLH1 binder that enhances prime editing efficiency by disrupting MMR, resulting in the highest PE efficiency to date.

This study uses CRISPR/Cas9 to delete A53T-SNCA in a rat model of Parkinson's disease, showing reduced -synuclein levels and improved motor symptoms.

The paper questions the claim that unexpected SNVs and indels in CRISPR-treated mice are caused by CRISPR-Cas9, highlighting the lack of validation for these off-target effects.

The paper demonstrates that NgAgo from Natronobacterium gregoryi cleaves RNA instead of DNA, functioning as a DNA-guided endoribonuclease.