Astrocyte immunosuppressive activity in glioblastoma depends on ZEB1 and is counteracted by CXCL14
Mathew Clement, Alex Gibbs, Ayesha Begum, Dorit Siebzehnrubl, Suresh Kaushik, Niharika Singh, Bhavana Gupta, Vasileios Eftychidis, Florian A. Siebzehnrübl
This study shows that ZEB1 in astrocytes suppresses glioblastoma immunity, and CXCL14 can counteract this effect to enhance T-cell activity and reduce tumor growth.
bioRxiv · May 13, 2026 · PreprintCancer Biology