Methods Matter -- Standard Production Platforms For Recombinant AAV Produce Chemically And Functionally Distinct Vectors
Neil G. Rumachik, Stacy Alyse Malaker, Nicole Poweleit, Lucy H. Maynard, Christopher M. Adams, Ryan D. Leib, Giana Cirolia, Dennis R. Thomas, Susan J. Stamnes, Kathleen H. Holt, Patrick L. Sinn, Andrew P. May, Nicole K. Paulk
This study compares rAAV production methods using different host cells, finding chemically and functionally distinct vectors with differences in PTMs, methylation, and potency.
Molecular Therapy — Methods & Clinical Development · May 21, 2020Peer-reviewedMolecular Biology