Ryan D. Leib

Phosphorylation-dependent binding of the Adenomatous Polyposis Coli protein to β-TrCP1 regulates β-catenin destruction

This study identifies phosphorylation-dependent binding of APC to β-TrCP1 as a mechanism regulating β-catenin destruction in Wnt signaling.

Fatty acid metabolism controls plasma membrane cholesterol accessibility via ATGL-dependent phospholipid remodeling

This study shows that fatty acid metabolism regulates plasma membrane cholesterol accessibility through ATGL-dependent phospholipid remodeling, affecting membrane fluidity and cholesterol signaling.

Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease

The paper identifies disease-associated states in PASMC and PAAF from IPAH patients and identifies potential modulators of PASMC phenotypic transition.

Proteins observed in scalp hair from preschool children

The paper identifies non-structural proteins in scalp hair from preschool children that show heritability and are linked to brain development, immune function, and stress response regulation, with age- and sex-related differences.

Methods Matter -- Standard Production Platforms For Recombinant AAV Produce Chemically And Functionally Distinct Vectors

This study compares rAAV production methods using different host cells, finding chemically and functionally distinct vectors with differences in PTMs, methylation, and potency.

HIPK4 is essential for murine spermiogenesis

This study shows HIPK4 is essential for spermiogenesis and male fertility in mice, with defects in sperm head morphology and fertility.