Genotoxic and metabolic stress drive divergent senescence programs in human microglia
Nisha Vincy Jose, Susan Janssens, Eunchai Kang, Bettina Platt
This study shows that chronic genotoxic and metabolic stress induce distinct yet overlapping senescence programs in human microglia, characterized by morphological changes, mitochondrial remodelling, and inflammatory activation.
bioRxiv · Sep 15, 2026 · PreprintNeuroscience