Bettina Platt

Genotoxic and metabolic stress drive divergent senescence programs in human microglia

This study shows that chronic genotoxic and metabolic stress induce distinct yet overlapping senescence programs in human microglia, characterized by morphological changes, mitochondrial remodelling, and inflammatory activation.

Reproducible social phenotyping of 5xFAD mice in the Agora maze (Sociobox)

The paper validates a new social behavior test for mice, showing wild-type mice can recognize strangers among 5 partners and 5xFAD mice show no deficit at 6-8 months.

DNA damage-induced senescence reshapes transcriptomic and functional landscape of human neural progenitor cells

This study establishes a human in vitro model of DNA damage-induced senescence in neural progenitor cells and identifies senescence-associated transcriptomic and functional changes linked to hippocampal ageing and neurodegeneration.

The Icelandic mutation APPA673T on amyloid-β plaque burden in the 5xFAD Alzheimer model

This study investigates the effect of the APPA673T mutation on amyloid-β plaque burden in 5xFAD mice, finding a significant reduction in plaque size but not in soluble Aβ levels.

The effect of the Icelandic mutation APPA673T in the line 66 model of tauopathy

This study investigates the effect of the APPA673T mutation on tau pathology and behavior in L66 tau transgenic mice, finding no significant modulation of tau pathology or behavioral deficits.

Mouse Exploratory behaviour in the open field with and without NAT-1 EEG device: Effects of MK801 and scopolamine

This study evaluates the impact of NAT-1 EEG devices on mouse behavior in the open field test with and without pharmacological treatments, finding minimal behavioral effects.

Effects of age and dietary methionine restriction on cognitive and behavioural phenotypes in the rTg4510 model of frontotemporal dementia

This study examines the effects of dietary methionine restriction on cognitive and behavioral phenotypes in a mouse model of frontotemporal dementia, finding improvements in motor function and memory in aged mice.

Pulsation changes link to impaired glymphatic function in a mouse model of vascular cognitive impairment

This study shows that bilateral common carotid stenosis impairs glymphatic function and vascular pulsation in mice, contributing to cognitive decline in vascular cognitive impairment.

Sex differences in behaviour and molecular pathology in the 5XFAD model

The paper examines sex differences in behavior and molecular pathology in 5XFAD mice, finding sex-specific differences in amyloid levels, inflammation, and cognitive performance.