ORMDL3-mediated SPT regulation Coordinates Myelin Sphingolipid and Protein Synthesis in Oligodendrocytes
Usha Mahawar, Raheema Fulani, Karli Mockenhaupt, Sumit Saha, Faheem Farooq, Fatemah S. Afshari, Susmita Manam, Carmen Sato‐Bigbee, Babette Fuss, Jeffrey L. Dupree, Tomasz Kordula, Binks W. Wattenberg
This study shows that ORMDL3 regulates sphingolipid and protein synthesis in oligodendrocytes, affecting myelin structure and composition during development.
bioRxiv · Sep 24, 2026 · PreprintBiochemistry