Tomasz Kordula

ORMDL3-mediated SPT regulation Coordinates Myelin Sphingolipid and Protein Synthesis in Oligodendrocytes

This study shows that ORMDL3 regulates sphingolipid and protein synthesis in oligodendrocytes, affecting myelin structure and composition during development.

Astrocyte-oligodendrocyte crosstalk dependent myelination via secreted protein YKL40

This study identifies YKL40 as a secreted protein mediating astrocyte-OPC communication to drive myelination during brain development.

NPC1 deficiency engages a lysosome - genome - immune program linked to neurodegeneration and cellular aging signatures

This study shows that NPC1 deficiency causes genomic instability and immune activation linked to neurodegeneration and aging, and identifies Fingolimod as a potential treatment.

Yin Yang 1 sets up the stage for cerebellar astrocyte maturation

This study identifies YY1's role in regulating cerebellar astrocyte maturation and maintenance in adult mice through single-cell RNA-seq analysis.