The paper integrates mRNA and protein isoform data in human RPE-1 cells to reveal widespread translation of alternative transcripts and proteolytic processing as a major source of proteome complexity.

Cell Reports · Sep 1, 2026Peer-reviewedSystems Biology

Gene Portals: A Framework for Integrating Clinical, Functional, and Structural Evidence into Rare Disease Variant Classification

Tobias Brünger, Ilona Krey, Suyeon Kim, Chiara Klöckner, Scott J. Myers, Katrine M. Johannesen, Arthur Stefanski, Gary Taylor, Eduardo Pérez‐Palma, Marie Macnee, Stéphanie Schorge, Rebekka S. Dahl, Hongjie Yuan, Riley E. Perszyk, Sukhan Kim, , Dennis Lal

The paper introduces Gene Portals, a framework that integrates clinical, functional, and structural data for rare disease variant classification, demonstrating its utility across five gene-specific portals.

medRxiv · Mar 6, 2026 · PreprintGenetic & Genomic Medicine

Precision at Every Scale: Efficiency in AI-Driven De Novo Antibody Design

Hyeonjin Cha, Kyesoo Cho, Jeonghyeon Gu, Daehyeon Gwak, Seung Woo Ham, Mirim Hong, Sehan Kim, Suyeon Kim, Sohee Kwon, Changsoo Lee, Dohoon Lee, Danyeong Lee, Dohoon Lee, Jungsub Lim, Jinsung Noh, , Jinsol Yang

This paper evaluates GaluxDesign, an AI platform, for de novo antibody design, showing a 10.5% binder rate and strong performance on benchmark targets.

bioRxiv · Nov 21, 2025 · PreprintBioengineering