Hongjie Yuan

The paper introduces Gene Portals, a framework that integrates clinical, functional, and structural data for rare disease variant classification, demonstrating its utility across five gene-specific portals.

The paper designs and evaluates novel PET tracers for CYP46A1 by modifying cyclopropyl groups, showing high affinity and suitable radiosynthesis.

The paper shows that eGlyRs in hippocampal interneurons regulate network activity through developmental and evolutionary conserved mechanisms.

The paper reports the synthesis of a high-affinity radioligand for O-GlcNAcase and its in vitro characterization.

This paper describes a GluN2C/GluN2D-selective NMDA receptor modulator that enhances inhibitory interneuron activity and gamma-band power, with potential therapeutic applications for neuropsychiatric disorders.

This study develops and evaluates [18F]P4B-2412 as a PET radioligand for imaging PDE4B, showing high binding, specificity, and metabolic stability in rodent models.

This study investigates the effects of the GRIN1 Y647S variant in mice, showing that β-hydroxybutyrate reduces convulsions associated with the variant.

This study shows that loss of Grin2a causes delayed electrophysiological maturation of hippocampal parvalbumin interneurons, leading to transient seizure susceptibility in mice.

This study models GRIN2A-related DEE in mice, identifies seizure and behavioral abnormalities, and evaluates treatment strategies.