Structural polymorphism of alpha-synuclein fibrils alters pathway of Hsc70 mediated disaggregation
Svenja Jäger, Jessica Tittelmeier, Thi Lieu Dang, Tracy Bellande, Virginie Redeker, Alexander Kai Buell, Janosch Hennig, Ronald Melki, Carmen I. Nussbaum-Krammer, Bernd Bukau, Anne S. Wentink
The paper shows that different structures of alpha-synuclein fibrils affect how Hsc70 chaperones disaggregate them, influencing protein quality control and aggregation.
The EMBO Journal · Oct 6, 2025Peer-reviewedBiochemistry