Carmen I. Nussbaum-Krammer

This study shows that disrupting sphingolipid metabolism reduces endolysosomal membrane fluidity, leading to rupture and tau aggregation, which can be mitigated by unsaturated fatty acids.

This study shows that shock wave exposure in C. elegans causes age-accelerated motor and sensory decline, with structural neuronal damage and cytoskeletal issues.

The paper shows that different structures of alpha-synuclein fibrils affect how Hsc70 chaperones disaggregate them, influencing protein quality control and aggregation.

This study evaluates the effectiveness of near-infrared light therapy for neurodegenerative diseases by measuring light penetration through human skulls and its biological effects on neurons and C. elegans.

The paper uses FLIM to study α-Syn polymorphs in cells, showing distinct fluorescence lifetimes and differential processing by clearance pathways, leading to increased seeding capacity.

This study shows that the Hsp70 disaggregation machinery disassembles Tau fibrils, generating small seeding-competent Tau species that can drive aggregation.