Jessica Tittelmeier

Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture

This study shows that disrupting sphingolipid metabolism reduces endolysosomal membrane fluidity, leading to rupture and tau aggregation, which can be mitigated by unsaturated fatty acids.

Explosive shock wave exposure leads to age-accelerated motor and sensory decline in C. elegans

This study shows that shock wave exposure in C. elegans causes age-accelerated motor and sensory decline, with structural neuronal damage and cytoskeletal issues.

Structural polymorphism of alpha-synuclein fibrils alters pathway of Hsc70 mediated disaggregation

The paper shows that different structures of alpha-synuclein fibrils affect how Hsc70 chaperones disaggregate them, influencing protein quality control and aggregation.

A Novel C. elegans Model for Tau spreading Reveals Genes Critical for Endolysosomal Integrity and Seeded Tau Aggregation

Evaluation of near-infrared light therapy for the treatment of neurodegenerative diseases: Limited penetration depth into the brain likely hinders efficacy

This study evaluates the effectiveness of near-infrared light therapy for neurodegenerative diseases by measuring light penetration through human skulls and its biological effects on neurons and C. elegans.

Dissecting aggregation and seeding dynamics of α-Syn polymorphs using the phasor approach to FLIM

The paper uses FLIM to study α-Syn polymorphs in cells, showing distinct fluorescence lifetimes and differential processing by clearance pathways, leading to increased seeding capacity.

DNA methyltransferase 1 (DNMT1) function is implicated in the age-related loss of cortical interneurons

This study shows that DNMT1 deletion in interneurons reduces age-related loss of cortical interneurons and improves somatomotor performance in mice.