Isogenic forebrain organoids uncover early neurodevelopmental alterations and imbalances in neuronal function leading to hyperexcitation in Gaucher disease
James A Crowe, Zuzana Matusova, Aline S Girard, Amélie Rajon, David Colameo, Leal Oburoglu, Oskar G. Zetterdahl, Joachim Björklund, Clàudia Puigsasllosas Pastor, Svenja Krupp, Ulf Ellervik, Alessio Cremonesi, Daniel Tornero, David Pentón, Henrik Ahlenius, , Isaac Canals
This study uses isogenic brain organoids to identify early neurodevelopmental changes and hyperexcitability in Gaucher disease, linking lipid dysregulation and neuronal function imbalances to clinical symptoms.
bioRxiv · Sep 29, 2026 · PreprintNeuroscience