Henrik Ahlenius

This study uses isogenic brain organoids to identify early neurodevelopmental changes and hyperexcitability in Gaucher disease, linking lipid dysregulation and neuronal function imbalances to clinical symptoms.

This study shows that Galectin-3 promotes tau pathology, neuroinflammation, white matter degeneration, and proteomic dysregulation, and that its deletion reduces these effects.

This study demonstrates that overexpressing OLIG2 and SOX10 in human astrocytes converts them into oligodendrocytes ex vivo, preserving brain architecture and showing potential for myelin repair in MS.

This paper identifies Flunarizine as a compound that inhibits radiation-induced astrocyte reactivity and improves survival in a glioblastoma model.

This study develops a method to efficiently generate human oligodendrocytes from induced pluripotent stem cells, which can form functional myelinating grafts in adult human brain tissue.