David Colameo

Isogenic forebrain organoids uncover early neurodevelopmental alterations and imbalances in neuronal function leading to hyperexcitation in Gaucher disease

This study uses isogenic brain organoids to identify early neurodevelopmental changes and hyperexcitability in Gaucher disease, linking lipid dysregulation and neuronal function imbalances to clinical symptoms.

A human-specific microRNA controls the timing of excitatory synaptogenesis

The paper identifies miR-1229-3p as a human-specific microRNA that delays neuronal synaptogenesis by reducing mitochondrial metabolism.

microRNA-218-5p Coordinates Scaling of Excitatory and Inhibitory Synapses during Homeostatic Synaptic Plasticity

This study identifies miR-218-5p as a regulator that coordinates excitatory and inhibitory synaptic scaling during homeostatic synaptic plasticity and sleep.

miR-329 and miR-495-mediated Prr7 downregulation isrequired for homeostatic synaptic depression in rathippocampal neurons

The paper identifies miR-329 and miR-495 as regulators of Prr7 downregulation, which is necessary for homeostatic synaptic depression in rat hippocampal neurons.

Blocking gephyrin phosphorylation or microglia BDNF signaling prevents synapse loss and reduces infarct volume after ischemia

Pervasive compartment-specific regulation of gene expression during homeostatic synaptic scaling

This study identifies compartment-specific gene expression changes during synaptic scaling in rat hippocampal neurons, revealing distinct regulatory mechanisms in somatic and process compartments.