NeuroscienceActa Neuropathologica CommunicationsPeer-reviewed
TDP-43 pathology is sufficient to drive axon initial segment plasticity and hyperexcitability of spinal motoneurones in vivo in the TDP43-ΔNLS model of Amyotrophic Lateral Sclerosis
Svetlana Djukic, Zhenxiang Zhao, Lasse Mathias Holmsted Jørgensen…·Claire Francesca Meehan
This study shows that TDP-43 pathology in the TDP43-ΔNLS mouse model drives hyperexcitability in spinal motoneurones, with reversible effects upon transgene resuppression.
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