Zhenxiang Zhao

Activity-dependent structural plasticity of myelinated axons tunes their excitability

The paper shows that activity can rapidly thin myelinated axons, increasing their excitability, and that this change is reversible and clinically relevant.

TDP-43 pathology is sufficient to drive axon initial segment plasticity and hyperexcitability of spinal motoneurones in vivo in the TDP43-ΔNLS model of Amyotrophic Lateral Sclerosis

This study shows that TDP-43 pathology in the TDP43-ΔNLS mouse model drives hyperexcitability in spinal motoneurones, with reversible effects upon transgene resuppression.