Anna Normann Bak

Discovery of the Honeycomb Synapse in Spinal Motor Circuits

The paper discovers a new synaptic structure called the Honeycomb Synapse in the spinal cord, showing its vulnerability in ALS models.

TDP-43 pathology is sufficient to drive axon initial segment plasticity and hyperexcitability of spinal motoneurones in vivo in the TDP43-ΔNLS model of Amyotrophic Lateral Sclerosis

This study shows that TDP-43 pathology in the TDP43-ΔNLS mouse model drives hyperexcitability in spinal motoneurones, with reversible effects upon transgene resuppression.

Cytoplasmic TDP-43 accumulation drives changes in C-bouton number and size in a mouse model of sporadic Amyotrophic Lateral Sclerosis

The paper shows that cytoplasmic TDP-43 accumulation in a mouse model leads to changes in C-bouton number and size, with sex-specific effects on motoneurones.