ECM-free patient-derived organoids preserve diverse prostate cancer lineages and uncover in vitro-enriched cell types
Robin Dolgos, Romuald Parmentier, Jing Wang, Raphaëlle Servant, Arnoud J. Templeton, Tobias Zellweger, Alastair D. Lamb, Kirsten D. Mertz, Svetozar Subotic, Tatjana Vlajnic, Hans‐Helge Seifert, Ashkan Mortezavi, Cyrill A. Rentsch, Lukas Bubendorf, Clémentine Le Magnen
This study develops an ECM-free culture system for prostate cancer organoids, revealing diverse tumor lineages and identifying in vitro-enriched cell types through single-cell RNA sequencing.
Cell Reports · Oct 1, 2025Peer-reviewedCancer Biology