Jing Wang

A modular patient-derived organoid-xenograft platform reveals molecular and clinical trajectories of prostate cancer progression

This study establishes a patient-derived organoid-xenograft platform that models prostate cancer progression, identifies biomarkers, and predicts treatment response.

ECM-free patient-derived organoids preserve diverse prostate cancer lineages and uncover in vitro-enriched cell types

This study develops an ECM-free culture system for prostate cancer organoids, revealing diverse tumor lineages and identifying in vitro-enriched cell types through single-cell RNA sequencing.

Lewy pathology in Parkinson's disease consists of a crowded organellar, membranous medley

The paper uses high-resolution imaging and biophysical methods to show that Lewy pathology in Parkinson's disease consists mainly of a crowded membranous medley of vesicles and dysmorphic organelles, with only a small fraction containing proteinaceous filaments.