25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner
Man Ying Wong, Michael Lewis, James Doherty, Yang Shi, Anil G. Cashikar, Anna Amelianchik, Svitlana Tymchuk, Patrick M. Sullivan, Mingxing Qian, Douglas F. Covey, Gregory A. Petsko, David M. Holtzman, Steven M. Paul, Wenjie Luo
This study shows that 25-HC enhances IL-1β production in microglia, particularly in apoE4-expressing cells, suggesting a role in AD neuroinflammation.
Journal of Neuroinflammation · Jun 17, 2020Peer-reviewedNeuroscience