Steven M. Paul

This study shows that 25-hydroxycholesterol mediates sex-specific proinflammatory responses in the brain by promoting microglia and astrocyte activation and neutrophil infiltration in a mouse model of LPS-induced neuroinflammation.

This study shows that Ch25h/25HC promotes neuroinflammation and neurodegeneration in a tauopathy mouse model by enhancing proinflammatory signaling and impairing sterol synthesis.

This study shows that 25-HC enhances IL-1β production in microglia, particularly in apoE4-expressing cells, suggesting a role in AD neuroinflammation.

This study compares whole hippocampus and subfield biomarkers for Alzheimer’s disease detection and prediction using multimodal MRI data, finding subiculum biomarkers improve prediction accuracy.

This paper introduces SuStaIn, a machine learning method that identifies disease subtypes and their temporal progression from cross-sectional data, improving prediction of diagnostic conversion in neurodegenerative diseases.

The paper examines the heritability of regional brain volumes using genetic and neuroimaging data from multiple cohorts, finding high heritability and consistent patterns across populations.