Michael Lewis

This study shows that chronic alcohol exposure impairs neurosteroid production and that enhancing neurosteroid levels can affect alcohol consumption and withdrawal behaviors.

This study shows that both direct and witnessed trauma reduce allopregnanolone levels and impair fear regulation in mice, suggesting neurosteroid deficits contribute to PTSD-like behaviors.

This study shows allopregnanolone modulates oscillatory states in the basolateral amygdala through delta-containing GABAA receptors, contributing to antidepressant effects.

This study shows that 25-HC enhances IL-1β production in microglia, particularly in apoE4-expressing cells, suggesting a role in AD neuroinflammation.