Anil G. Cashikar

25-hydroxycholesterol mediates brain cytokine production and neutrophil infiltration in a mouse model of lipopolysaccharide-induced neuroinflammation

This study shows that 25-hydroxycholesterol mediates sex-specific proinflammatory responses in the brain by promoting microglia and astrocyte activation and neutrophil infiltration in a mouse model of LPS-induced neuroinflammation.

Microglial 25-hydroxycholesterol mediates neuroinflammation and neurodegeneration ina tauopathy mouse model

This study shows that Ch25h/25HC promotes neuroinflammation and neurodegeneration in a tauopathy mouse model by enhancing proinflammatory signaling and impairing sterol synthesis.

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

This study shows that 25-HC enhances IL-1β production in microglia, particularly in apoE4-expressing cells, suggesting a role in AD neuroinflammation.