Removal of a genomic duplication by double-nicking CRISPR restores synaptic transmission and behavior in the MyosinVA mutant mouse Flailer.
Fernando J. Bustos, Swarna Pandian, Henny Haensgen, Jian-Ping Zhao, Haley Strouf, Matthias Heidenreich, Lukasz J. Swiech, Benjamin E. Deverman, Viviana Gradinaru, Feng Zhang, Martha Constantine‐Paton
This study removes a genomic duplication in a mouse model using DN-CRISPRs, improving synaptic transmission and behavior.
bioRxiv · Apr 28, 2023 · PreprintNeuroscience