Role of a childhood cancer-linked BRIP1/FANCJ germline variant in genomic instability and cancer cell vulnerability
Sahar Karbassi, Teodora Nikolova, Daniela Pfeiffer, Swaroopa Nakkeeran, Roopesh Anand, Pierre‐Olivier Frappart, Michaela Kuhlen, Thomas G. Hofmann
This study identifies a germline BRIP1 variant linked to childhood cancer, showing it causes genomic instability and creates therapeutic vulnerabilities.
bioRxiv · Mar 30, 2026 · PreprintCancer Biology