Author

Daniela Pfeiffer

Johannes Gutenberg University MainzORCID 0000-0003-2002-8337Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Pierre‐Olivier FrappartiD· 2 shared Sahar Karbassi· 2 shared Teodora NikolovaiD· 2 shared Thomas G. HofmanniD· 2 shared Georg Nagel· 1 shared Huong Becker· 1 shared Kaveri Raja· 1 shared Magdalena C. LiebliD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Pierre‐Olivier FrappartORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

HIPK2 regulates homology-directed DNA repair and PARP inhibitor sensitivity

Patrick Weyerhäuser, Pierre‐Olivier Frappart, Georg Nagel, Stephan Krieg, Teodora Nikolova, Wynand Paul Roos, Kaveri Raja, Sahar Karbassi, Steffen Dickopf, Magdalena C. Liebl, Daniela Pfeiffer, Huong Becker, Yang He, Markus Christmann, Matthias Altmeyer, Thomas G. Hofmann

This study identifies HIPK2's role in HR repair and PARPi sensitivity by regulating BRCA1 stability, suggesting HIPK2 inhibition as a therapeutic strategy for BRCA1-proficient cancers.

bioRxiv · Jun 1, 2026 · PreprintCell Biology

Role of a childhood cancer-linked BRIP1/FANCJ germline variant in genomic instability and cancer cell vulnerability

Sahar Karbassi, Teodora Nikolova, Daniela Pfeiffer, Swaroopa Nakkeeran, Roopesh Anand, Pierre‐Olivier Frappart, Michaela Kuhlen, Thomas G. Hofmann

This study identifies a germline BRIP1 variant linked to childhood cancer, showing it causes genomic instability and creates therapeutic vulnerabilities.

bioRxiv · Mar 30, 2026 · PreprintCancer Biology