Author

Thomas G. Hofmann

Johannes Gutenberg University MainzORCID 0000-0003-0547-2720Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Daniela PfeifferiD· 2 shared Pierre‐Olivier FrappartiD· 2 shared Sahar Karbassi· 2 shared Teodora NikolovaiD· 2 shared Anthony Gabry da SilveiraiD· 1 shared Ari WaismaniD· 1 shared Beatriz Leocata· 1 shared Bruno Junior NevesiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

Daniela PfeifferORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintJun 1, 2026

HIPK2 regulates homology-directed DNA repair and PARP inhibitor sensitivity

Patrick Weyerhäuser, Pierre‐Olivier Frappart, Georg Nagel…·Thomas G. Hofmann

This study identifies HIPK2's role in HR repair and PARPi sensitivity by regulating BRCA1 stability, suggesting HIPK2 inhibition as a therapeutic strategy for BRCA1-proficient cancers.

DOI 10.64898/2026.05.28.728554

humanexperimental assay

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ImmunologyNature CommunicationsPeer-reviewedApr 1, 2026

Th17 cells require the DNA repair sensor XPC to control oxidative DNA damage

Jefferson Antônio Leite, Natalia Notarberardino Bos, Luísa Menezes-Silva…·Niels Olsen Saraiva Câmara

This study identifies XPC as essential for protecting Th17 cells from oxidative DNA damage, showing its role in DNA repair, differentiation, and function.

DOI 10.1038/s41467-026-69914-y

mouseDNA methylation

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Cancer BiologybioRxivPreprintMar 30, 2026

Role of a childhood cancer-linked BRIP1/FANCJ germline variant in genomic instability and cancer cell vulnerability

Sahar Karbassi, Teodora Nikolova, Daniela Pfeiffer…·Thomas G. Hofmann

This study identifies a germline BRIP1 variant linked to childhood cancer, showing it causes genomic instability and creates therapeutic vulnerabilities.

DOI 10.64898/2026.03.24.714005

humanwhole-exome sequencing

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