Association of cerebellar inflammation and neurodegeneration in a novel spinocerebellar ataxia type 13 mouse model
Junxiang Yin, Jennifer White, Swati Khare, Michael Wu, Aamir R. Zuberi, Ming Gao, Jerelyn A. Nick, Cathleen M. Lutz, Kyle D. Allen, Harry S. Nick, Michael F. Waters
This study creates a novel SCA13 mouse model with a R424H mutation, showing motor deficits, Purkinje cell loss, cerebellar inflammation, and atrophy, linking neuroinflammation to neurodegeneration.
bioRxiv · Oct 28, 2024 · PreprintNeuroscience